Recent advancements in reaction control and method development strategies have significantly impacted the way in which synthetic 新利手机客户端chemistry is performed.可以说，其中一个最广泛的可接受和使能技术是continuous flow 新利手机客户端chemistry，请在成本上比批量生产有优势，reaction efficiency and safety.它的实施改变了我们思考和进行化学的方式，在某些领域扩大了我们的合成能力。新利手机客户端
As a result,numerous syntheses of commercially and pharmaceutically relevant compounds are being redesigned around flow processes in order to improve efficiency and reproducibility.此外，the flow reactor configuration can be readily customized to meet specific reaction demands.
These changes are most evident within the pharmaceutical industry where increasing pressure to continually identify and optimize lead compounds has renewed interest in the development of sustainable and cost effective processes for both research and production purposes.1
A direct example of this comes from Prof.Ian Baxendale's laboratory at Durham University.二杂环基序普遍存在于药物中，是有机化学研究的最大领域之一。新利手机客户端Through a convenient telescope continuous flow process,ethyl isocyanoacetate—a highly sensitive and reactive compound frequently used as a key building block in heterocycle synthesis—was generatedin situ并以收敛的方式合成各种杂环结构。
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| 1,2,4-三唑和吡咯[1,2]多步流合成的一般反应方案-C]pyrimidine-based heterocycles. |
与危险放热过程有关的连续流量限制问题，反应放大和高活性或有毒中间体的处理，overcoming numerous safety concerns inherent in batch 新利手机客户端chemistry.此外，flow chemistries have also been combined with additional features such as microwave irradiation,solid-supported reagents or catalysts,光化学，新利手机客户端感应加热和电化学，新利手机客户端大大提高了它在合成有机化学中的应用。新利手机客户端3、4
Significant developments within the last decade indicate that the full potential of flow 新利手机客户端chemistry has yet to be realized.As with any new up-and-coming technology,there exist limitations that more and more researchers are willing to tackle.This is evident in the prevalence of flow systems now being utilized not only within academic laboratories but also in industrial institutions.
Interesting and innovative examples of synthetic reactions translated to flow systems have recently been published inOrganic and Biomolecular 新利手机客户端Chemistry也可以在关节处找到OBC/CHEMCOMM公司collection ‘Recent Advances in Flow Synthesis and Continuous Processing'.Select examples are discussed below.
Establishing a multistep continuous flow process is a logical step forward in the development of flow technology.However,genuine applications remain limited due to inherent challenges such as solvent incompatibility,中间检查和稀释效果。教授Floris Rutjes and his coworkers at Radboud University have provided a solution to this problem. 5个它们有效地整合了两步化学酶流合成不相容反应步骤。 通过使用直列液-液分离模块。
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| 由于难以与产品原料分离，贵金属回收困难，同质金属催化在工业过程中的应用受到限制。为了补救这个问题，an immobilised iridium hydrogen transfer catalyst was developed by Prof.Ian Baxendale及其同事通过将配体并入多孔聚合物整体流动反应器中用于基于流动的系统，这限制了金属的浸出和催化剂的失活。6 |
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| 使用固定化铱氢转移催化剂的整体反应器测试配置。 |
最后，教授Bradely Pentolute及其麻省理工学院的研究小组最近报告了一种有效的连续流动系统，用于具有挑战性的合成含全氟原子分子的肽，取代不稳定的二硫键。7Application of a rapid flow-based solid-phase peptide synthesis allowed the researchers to circumvent previously encountered problems associated with this 新利手机客户端chemistry and has resulted in an overall improvement in quality and isolated yield of the peptides.
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| Flow system for the synthesis of H2 relaxin fragment analogues using modified solid-phase peptide synthesis |
要了解更多信息，请参阅：
1 闪蒸化学：不新利手机客户端能成批进行的流动化学。.J.吉田，是的。Takahashi,A.长崎，化学公社。，请2013年，请49岁，请9896.DOI: 10.1039/c3cc44709j
二Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-C]嘧啶类。 M.鲍曼。A.M.罗德里格斯·加西亚，I.R.Baxendale,组织生物醇。化学，2015年，请13，请4231页。DOI:10.1039/C5OB00245A
三连续流动微反应器中的液相氧化化学。新利手机客户端H.P.L.杰莫茨，是的。Su,M.尚，V.海塞尔，R.卢克，T.不，我，化学Soc.Rev.，请2016年，请45岁，请83.DOI:10.1039/C5CS00447K
4 Flow 新利手机客户端chemistry syntheses of natural products. J.C.过去，D.L.布朗，S.V.利，化学Soc.Rev.，请2013年，请42，请8849页。DOI:10.1039/C3CS60246J
5个Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives. 上午Delville,K.科赫，J.C.M.范·赫特，F.P.J.T.金红石，组织生物醇。化学，2015年，请13，请1634.DOI:10.1039/c4ob02128b
6A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions. M.V.罗霍，L.Guetzoyan,I.R.Baxendale,组织生物醇。化学，请2015,13，请1768年。DOI:10.1039/C4OB02376E
7 一种通过基于快速流的肽合成实现的H2松弛素的全氟非生物类似物。 T.Luhmann,S.K.Mong,M.D.Smino,L.迈内尔，B.L.五洗脱液，组织生物醇。化学，请2016年，请14，请3345.DOI:10.1039/C6OB00208K型
维多利亚无胸衣目前正在完成她的博士学位。in organic 新利手机客户端chemistry with Prof.多伦多大学的安德烈·尤丁。Her research is centred on the synthesis of kinetically amphoteric molecules,它为化学选择性转化的发展提供了一个多功能的平台，特别强调创造新的生物活性分子。
