MedChemComm Blog

我们很高兴与您分享一系列研究论文，审查文章和关于抗菌性抵抗议题（AMR）的书籍。关于抗生素抗性威胁，更广泛的AMR，对人体健康，全球粮食生产和经济繁荣的警告正在接受增加的媒体利益。到2050年，据估计，没有协调的行动，1000万人可能会死于以前治愈的疾病。 © iStock “At the end of this month, the World Health Organisation (WHO) will present their draft global action plan on AMR at the 68th World Health Assembly in Geneva, it is timely to consider the importance of chemistry in tackling antimicrobial resistance,” commentsSylvie Garneau-Tsodikova教授, Editorial Board member ofMedChemComm“This collection showcases the essential contributions of chemical science to understanding antibiotic resistance, developing new treatments, diagnostics and mitigations strategies to tackle this global threat.” “The chemical sciences play a pivotal role in a sustainable and prosperous future” saysDominic Tildesley，皇家化学学会总裁“是否发展新的抗生素，以打击感染，将废物转化为能源，或新利手机客户端开发高效的太阳能电池，化学家正在设计和应用明天的技术”。 All articles are freely available until 18th June. All books included here have their first chapter free to read. Learn more about our work to support the chemical sciences community working on solutions in climate change, energy, food, health and water. Having trouble acessing the articles? Remeber to login in to you free personal account to see all our free content. Don’t have a free account? It’s quick and easy tocreate one now。

---

Why is it important to address AMR?

Thomas Fleming outlines the role of chemistry in tackling antibiotic resistance as part of our recent chemistry in health video competition	击败超级术 - 避免抗生素天启- 由Michael Moseley，科学记者和电视演示者主持的公共小组讨论，与科学家和政策制定者讨论解决AMR新利手机客户端的挑战和可能的解决方案。

---

新抗菌剂的设计与合成

评论和观点:

植物作为新的抗微生物和抗性改性剂的来源
Ana Cristina Abreu, Andrew J. McBain and Manuel Simões
Nat. Prod. Rep.,DOI: 10.1039/C2NP20035J, Review Article

Antibiotics from myxobacteria
Till F. Schäberle, Friederike Lohr, Alexander Schmitz and Gabriele M. König
Nat. Prod. Rep。，DOI：10.1039 / C4NP00011K，审查文章

糖肽树枝状大分子作为假单胞菌铜绿假单胞菌生物膜抑制剂
Jean-Louis Reymond, Myriam Bergmann and Tamis Darbre
化学。SOC。录。,DOI: 10.1039/C3CS35504G, Review Article

Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics
B.o Li, Walter J. Wever, Christopher T. Walsh and Albert A. Bowers
Nat. Prod. Rep。，DOI：10.1039 / C3NP70106A，审查文章

Ruthenium complexes as antimicrobial agents
Fangfei Li, J. Grant Collins and F. Richard Keene
化学。SOC。录。,DOI: 10.1039/C4CS00343H, Review Article

AApeptides as a new class of antimicrobial agents
Youhong Niu, Haifan Wu, Yaqiong Li, Yaogang Hu, Shruti Padhee, Qi Li, Chuanhai Cao and Jianfeng Cai
org。生物摩尔。化学。, DOI: 10.1039/C3OB40444G, Perspective

B.enzyl-substituted metallocarbene antibiotics and anticancer drugs
F. Hackenberg and M. Tacke
Dalton Trans。，DOI：10.1039 / C4DT00624K，透视

Siderophore-dependent iron uptake systems as gates for antibiotic Trojan horse strategies against假单胞菌铜绿假单胞菌
Gaëtan L. A. Mislin and Isabelle J. Schalk
金属化学，DOI：10.1039 / C3MT00359K，MINIREVIEW

Design and synthesis of membrane-targeting antibiotics: from peptides- to aminosugar-based antimicrobial cationic amphiphiles
Ido M. Herzog和Micha Fridman
Med。化学。Commun。，DOI：10.1039 / C4MD00012A，审查文章

---

原始研究文章：

Synthesis of antimicrobial cyclodextrins bearing polyarylamino and polyalkylamino groups通过click chemistry for bacterial membrane disruption
Hatsuo Yamamura, Yuuki Sugiyama, Kensuke Murata, Takanori Yokoi, Ryuji Kurata, Atsushi Miyagawa, Kenji Sakamoto, Keiko Komagoe, Tsuyoshi Inoue and Takashi Katsu
化学。安排。, DOI: 10.1039/C3CC49543D, Communication

Phenazine antibiotic inspired discovery of potent bromophenazine antibacterial agents againstStaphylococcus aureusandStaphylococcus epidermidis
Nicholas V. Borrero, Fang Bai, Cristian Perez, Benjamin Q. Duong, James R. Rocca, Shouguang Jin and Robert W. Huigens III
org。生物摩尔。Chem。, DOI: 10.1039/C3OB42416B, Communication

具有可调谐侧链两亲性的聚合物作为非溶血性抗菌剂
Divakara S. S. M. Uppu, Padma Akkapeddi, Goutham B. Manjunath, Venkateswarlu Yarlagadda, Jiaul Hoque and Jayanta Haldar
化学。Commun。, DOI: 10.1039/C3CC43751E, Communication

尿嘧啶肽抗生素的作用机制：翻译酶MRAY中蛋白质 - 蛋白质相互作用位点的意外链接
Timothy Bugg, Maria Rodolis, Agnes Mihalyi, Christian Ducho, Kornelia Eitel, Bertolt Gust and Rebecca Jane Miriam Goss
化学。Commun。, DOI: 10.1039/C4CC06516F, Communication

Tailored lysozyme–ZnO nanoparticle conjugates as nanoantibiotics
Nirmalya Tripathy，Rafiq Ahmad，Seung Hyuck Bang，Jiho Min和Yoon-Bong Hahn
化学。Commun。, DOI: 10.1039/C4CC03712J, Communication

细菌细菌靶细菌膜的抑制剂in vivo
Marie H. Foss，Ye-Jin Eun，Charles I. Grove，Daniel A. Pauw，Noheme A. Soreo，Jarred W. Rensvold，David J. Pagliarini，Jared T. Shaw和Douglas B. Weibel
Med。化学。Commun。, DOI: 10.1039/C2MD20127E, Concise Article

A structure activity-relationship study of the bacterial signal molecule HHQ reveals swarming motility inhibition in芽孢杆菌萎缩
F. Jerry Reen, Rachel Shanahan, Rafael Cano, Fergal O’Gara and Gerard P. McGlacken
org。生物摩尔。化学。, DOI: 10.1039/C5OB00315F, Paper

An organometallic structure-activity relationship study reveals the essential role of a Re(CO)_3.moiety in the activity against gram-positive pathogens including MRSA
Malay Patra, Michaela Wenzel, Pascal Prochnow, Vanessa Pierroz, Gilles Gasser, Julia E. Bandow and Nils Metzler-Nolte
化学。科学。, DOI: 10.1039/C4SC02709D, Edge Article

非典型β-碳酸酐酶抑制剂 - 朝新抗分枝杆菌
Natascha von Gnielinski，Lisa Nienaber，Lyndel Mason，Samantha Ellis，James A. Triccas，Rohan A. Davis和Andreas Hofmann
Med。化学。Commun。，DOI：10.1039 / C4MD00310A，简明文章

Indole-based novel small molecules for the modulation of bacterial signalling pathways
Nripendra Nath Biswas, Samuel K. Kutty, Nicolas Barraud, George M. Iskander, Renate Griffith, Scott A. Rice, Mark Willcox, David StC. Black and Naresh Kumar
org。生物摩尔。Chem。，DOI：10.1039 / C4OB02096K，纸张

Synthesis, antiribosomal and antibacterial activity of 4′-O.-glycopyranosyl paromomycin aminoglycoside antibiotics
Weiwei Chen, Takahiko Matsushita, Dimitri Shcherbakov, Heithem Boukari, Andrea Vasella, Erik C. Böttger and David Crich
Med。化学。Commun。, DOI: 10.1039/C4MD00119B, Concise Article

Antibacterial activity of adamantyl substituted cyclohexane diamine derivatives against methicillin resistantStaphylococcus aureusandMycobacterium tuberculosis
Deapauk Kumar，Widuranga Kumbukgolla，Sampath Jayaweera，Maiann Bailey，Torey Alling，Juliane Olinger，Tanya Parish和Diwan S. Rawat
RSC Adv。, DOI: 10.1039/C4RA00224E, Paper

N-Substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1,3-bis(塔特-butoxycarbonyl)guanidine cyclization
Andrew A. Yeagley, Zhaoming Su, Kára D. McCullough, Roberta J. Worthington and Christian Melander
org。生物摩尔。化学。,DOI: 10.1039/C2OB26469B, Paper

钌（II）复合物作为局部抗生素的钌（II）复合物的发展Staphylococcus aureus
P.-L. Lam, G.-L. Lu, K.-M. Hon, K.-W. Lee, C.-L. Ho, X. Wang, J. C.-O. Tang, K.-H. Lam, R. S.-M. Wong, S. H.-L. Kok, Z.-X. Bian, H. Li, K. K.-H. Lee, R. Gambari, C.-H. Chui and W.-Y. Wong
Dalton Trans。, DOI: 10.1039/C3DT52879K, Paper

Synthesis and biological activity of novel bis-indole inhibitors of bacterial transcription initiation complex formation
Marcin Mielczarek, Ruth V. Devakaram, Cong Ma, Xiao Yang, Hakan Kandemir, Bambang Purwono, David StC. Black, Renate Griffith, Peter J. Lewis and Naresh Kumar
org。生物摩尔。Chem。, DOI: 10.1039/C4OB00460D, Paper

（±）-platencin抗耐药性和广泛的耐药性强化生长抑制活性Mycobacterium tuberculosis
Gamal A. I. Moustafa, Shoji Nojima, Yoshi Yamano, Akio Aono, Masayoshi Arai, Satoshi Mitarai, Tetsuaki Tanaka and Takehiko Yoshimitsu
Med。化学。Commun。, DOI: 10.1039/C3MD00016H, Concise Article

Thiazole-based aminopyrimidines andN-phenylpyrazolines as potent antimicrobial agents: synthesis and biological evaluation
Konstantinos Liaras, Athina Geronikaki, Jasmina Glamočlija, Ana Ćirić and Marina Soković
Med。化学。Commun。, DOI: 10.1039/C4MD00124A, Concise Article

Chlorido-containing ruthenium(II) and iridium(III) complexes as antimicrobial agents
Mallesh Pandrala, Fangfei Li, Marshall Feterl, Yanyan Mulyana, Jeffrey M. Warner, Lynne Wallace, F. Richard Keene and J. Grant Collins
Dalton Trans。, DOI: 10.1039/C3DT32775B, Paper

Highly active antibacterial ferrocenoylated or ruthenocenoylated Arg-Trp peptides can be discovered by an L-to-D substitution scan
H. Bauke Albada，Pascal Prochnow，Sandra Bobersky，Julia E. Bandow和Nils Metzler-Nolte
化学。Sci。, DOI: 10.1039/C4SC01822B, Edge Article

---

Infection prevention and alternatives to address AMR

书籍和评论：

Polymeric Materials with Antimicrobial Activity: From Synthesis to Applications
Alexandra Muñoz-Bonilla (Editor), María Cerrada (Editor), Marta Fernández-García (Editor)
ISBN (print): 978-1-84973-807-1, Copyright: 2013

Silver in Healthcare: Its Antimicrobial Efficacy and Safety in Use
Alan B. G. Lansdown (Author)
ISBN (print): 978-1-84973-006-8, Copyright: 2010

微生物病原体的光动力灭活：医疗和环境应用
Michael R Hamblin (Editor), Giulio Jori (Editor)
ISBN (print): 978-1-84973-144-7, Copyright: 2011

Towards bacterial adhesion-based therapeutics and detection methods
NúriaPareraPera和Roland J. Pieters
Med。化学。安排。, DOI:10.1039/C3MD00346A, Review Article

Superhydrophobic surfaces for the reduction of bacterial adhesion
萧夏张，凌王和埃尔克基·莱温
RSC Adv。, DOI: 10.1039/C3RA40497H, Review Article

Nanosilver-based antibacterial drugs and devices: Mechanisms, methodological drawbacks, and guidelines
Loris Rizzello and Pier Paolo Pompa
化学。SOC。录。，DOI：10.1039 / C3CS60218D，审查文章

---

原始研究文章：

Antimicrobial nanotechnology: its potential for the effective management of microbial drug resistance and implications for research needs in microbial nanotoxicology
Deborah M. Aruguete, Bojeong Kim, Michael F. Hochella, Yanjun Ma, Yingwen Cheng, Andy Hoegh, Jie Liu and Amy Pruden
环绕。科学。:过程的影响, DOI: 10.1039/C2EM30692A, Critical Review

The promotion of antimicrobial activity on silicon substrates using a “click” immobilized short peptide
Lin Wang, Junjian Chen, Lin Shi, Zhifeng Shi, Li Ren and Yingjun Wang
化学。Commun。, DOI: 10.1039/C3CC47922F, Communication

An efficient strategy to achieve hydrophilic polymeric silver(I) materials with exceptional antibacterial activity
Sheng-Chun Chen, Zhi-Hui Zhang, Qun Chen, Li-Qun Wang, Juan Xu, Ming-Yang He, Miao Du, Xiao-Ping Yang and Richard A. Jones
化学。Commun。, DOI: 10.1039/C2CC36538C, Communication

Silver nanoparticle-embedded polymersome nanocarriers for the treatment of antibiotic-resistant infections
Benjamin M. Geilich，Anne L. Van de Ven，Gloria L. Singleton，LiudaJ.Sepúlveda，Srinivas Sridhar和Thomas J. Webster
Nanoscale, DOI: 10.1039/C4NR05823B, Paper

Antibacterial polymeric nanostructures for biomedical applications
Jing Chen, Fangyingkai Wang, Qiuming Liu and Jianzhong Du
化学。Commun, DOI: 10.1039 / C4CC03001J,专题文章

Magnetic hybrid colloids decorated with Ag nanoparticles bite away bacteria and chemisorb viruses
Hye Hun Park, SungJun Park, GwangPyo Ko and Kyoungja Woo
J. Mater。化学。B., DOI: 10.1039/C3TB20311E, Paper

Covalent attachment of multilayers (CAM): a platform for pH switchable antimicrobial and anticoagulant polymeric surfaces
Heather A. Pearson，Joseph M. Andrie和Marek W.城市
B.iomater. Sci。, DOI: 10.1039/C3BM60238A, Paper

Multi-scale strategy to eradicate假单胞菌铜绿假单胞菌on surfaces using solid lipid nanoparticles loaded with free fatty acids
Erik N. Taylor, Kim M. Kummer, Deepti Dyondi, Thomas J. Webster and Rinti Banerjee
Nanoscale, DOI: 10.1039/C3NR04270G, Paper

B.io-inspired resin acid-derived materials as anti-bacterial resistance agents with unexpected activities
Mitra S. Ganewatta, Yung Pin Chen, Jifu Wang, Jihua Zhou, Jerry Ebalunode, Mitzi Nagarkatti, Alan W. Decho and Chuanbing Tang
化学。Sci。, 2014, DOI: 10.1039/C4SC00034J, Edge Article

Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria
Ricardo Ferraz, Vânia Teixeira, Débora Rodrigues, Rúben Fernandes, Cristina Prudêncio, João Paulo Noronha, Željko Petrovski and Luís C. Branco
RSC Adv。, DOI: 10.1039/C3RA44286A, Paper

The surface charge of anti-bacterial coatings alters motility and biofilm architecture
O.lena Rzhepishevska, Shoghik Hakobyan, Rohit Ruhal, Julien Gautrot, David Barbero and Madeleine Ramstedt
B.iomater. Sci。, DOI: 10.1039/C3BM00197K, Paper

Studies of the drug resistance response of sensitive and drug-resistant strains in a microfluidic system
湘潭江，余康，兴杰潘，朱宇，齐欧阳和春雄罗
积分。BIOL.。，DOI：10.1039 / C3IB40164B，纸张