Archive for the ‘Board News’ Category

Introducing Editorial Board member David Walt

The fifth Introducing series post is all about new Editorial Board member David Walt. We’re very pleased to welcome David to the board and here he introduces his background and research vision:

David R. Walt是化学的罗宾森教授,生物医学工程,遗传学教授教授,新利手机客户端口腔医学教授塔夫茨大学and is a霍华德休斯医学研究所教授。沃尔特博士的创始科学家Illumina公司and has been a Director and Chairman of its Scientific Advisory Board since 1998. Dr. Walt is also the Founding Scientist ofQuanterix公司并一直是其科学顾问委员会的董事及主席自2007年以来,他获得多项国家和国际奖项和荣誉,在光学传感器和阵列领域他的基本和应用工作。沃尔特博士的一员Board on Chemical Sciences and Technology of the U.S. National Academy of Sciences。他的一个成员工程的美国国家科学院,American Academy of Arts and Sciences, a fellow of theAmerican Institute for Medical and Biological Engineering和的老乡American Association for the Advancement of Science。He received a B.S. in Chemistry from theUniversity of Michigan和博士学位。从化学生物学石溪大学

研究视野: “观察单个分子的能力已成为常规作为与光源,检测器,信号处理算法,和分子结构改进的结果内置扩增。单分子研究使超灵敏的测量。毕竟,一个人不能比计算分子衡量事物更精确。相比于本体的测量,数以百万计的分子或多个观察到,只能够获得一个平均结果,单分子的研究提供了观察群体内的不均匀性,包括与不寻常的特性罕见的异常值的能力。微与纳米流体将是限制单个分子在超小的体积,以方便他们的观察和检测关键技术。我的实验室着重于测量单个分子和单个细胞。我们的单分子研究涉及的基本酶学超敏感检测蛋白质和核酸。单细胞研究,使我们能够观察对那些可能使我们阐明细胞是如何罕见导致癌症等疾病的细胞活动的分布。我们采用了一系列的工具,包括芯片,微孔,微球和微流体“。
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介绍编委会成员马克·吉利根

我们在本周的一系列介绍后非常高兴地欢迎新的编委会成员马克·吉利根。他描述了他从航空航天工程在发展微流控芯片的不断增加,应用范围的商业成功不寻常的路:

关口研究航天工程Cranfield,之后曾在两Formula 1 for Benettonand Aerospace forBAe Commercial aircraft。马克再接着工作Pitney Bowes公司in the US developing franking machines andPhilipsin the Netherlands developing the first DVD drives. Then in 1997 Mark moved to work for a technology consulting consultancy calledThe Technology Partnership(TTP) and started working on the interfaces between Engineering and Life Sciences. One major project atTTPwas called Myriad, and involved working in conjunction with seven pharmaceutical companies to develop highly automated robotic systems for parallel chemistry to make potential drug candidates. The outcome of this project was sold to梅特勒 - 托利多and a new business unit was formed and built with Mark leading the R&D of that new company. Once this company was built in 2000, Mark moved into New Ventures for Mettler, investigating and acquiring businesses in automated chemistry.

In 2001 Mark left Mettler Toledo to foundSyrris,目前已成长为最先进的工具和技术的合成化学,包括微反应器的全球领导者。新利手机客户端如Syrris增长,一些多功能微流控技术进行了开发和合作伙伴日益多元化试图访问它们。这导致形成白云石微流控in 2005, which then won a large UK government grant to create a Microfluidic Application Centre. This trend of starting new brands has carried on and now Mark is the CEO of theBlacktrace集团of companies which includesSyrris,白云石and a number of其他品牌它们都统称集中在科学的产品化新利手机客户端

PRACTICAL MICROFLUIDICS: Mark’s interests specifically in microfluidics are around generating practical real world solutions to make microfluidics become an increasingly commercially successful technology. This is about spotting the common issues across multiple application areas and developing underlying technology and componentry to solve these issues. Together with this component focus, Mark is interested in standards around formats and interconnectivity. Mark is application area agnostic, however, microdroplets are currently a strong theme across a number of areas from molecular biology to food and drug delivery. Mark is focussed on providing workable solutions by designing, developing and arranging manufacture, marketing and sales. However, although白云石拥有自己的无尘室的设备,马克的团队与许多其他公司的微流体装置已经量产的原型。

总体来看,马克热衷于获得科学和技术的新功能,可以通过更广泛和更广泛的观众实际易于使用的开发使用的重点为商业上可行的产品。新利手机客户端

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介绍编委会成员霍尔格·贝克尔

For the third post in the Introducing series, here we’re very happy to introduce you to Editorial Board member Holger Becker and his research vision, including the development of lab on a chip technology to marketable products:

霍尔格·贝克尔博士是共同创始人和CSO的微流体ChipShop有限公司。He obtained physics degrees from theUniversity of Western Australia/Perth and the海德堡大学in 1990 and 1991 respectively. He started to work on miniaturized systems for chemical analysis during his PhD thesis at the Institute for Applied Physics at Heidelberg University, where he obtained his PhD on miniaturized chemical surface acoustic wave (SAW) sensors in 1995. Between 1995 and 1997 he was a Research Associate at the化学系在伦敦皇家学院新利手机客户端安德烈亚斯·曼茨教授。In 1998 he joinedJENOPTIK Mikrotechnik有限公司where he was responsible for the realisation of a polymer-based microfabrication production line. Since then, he founded and led several companies in the field of microsystem technologies in medicine and the life sciences, for which he was nominated for the German Founder’s Prize in 2004. He lead the Industry Group of the德国物理学会between 2004 and 2009, and is the current chair of theSPIE ‘‘Microfluidics, BioMEMS and Medical Microsystems’’ conferenceas well as co-chair forMicroTAS 2013。除了对编委会服务“实验室的单晶片”,他的一名成员MANCEF总顾问委员会(微纳米技术商业化教育基金会),“安全研究”的专家小组Federal Ministry of Economics and Technologyas well as several other advisory boards and is acting as a regular reviewer of project proposals on a national and international level.

研究视野:作为实验室上的单芯片技术使巨大的进步对他们从一个纯粹的科学话题到商业上可用的实现技术转型,我们的行业集中在三个主要领域的工作:在微流体结构的设计方面,明确trend towards fully integrated devices, i.e. devices which can perform a complete analytical or diagnostic process from sample input to result output, can be observed. We have over the years developed a microfluidic toolbox which allows a rapid development and validation of such integrated devices. The second field is the development of commercially viable back-end processing technologies. In higher volume production, these processes such as heterogeneous integration of sensors, filters or membranes, assembly, bonding, reagent storage or surface modifications, can make up to 80% of the overall manufacturing cost of a microfluidic device and many solutions which are used by the academic community cannot be scaled to higher volume manufacturing. For a commercial success however, manufacturing cost play a decisive role and research into these processes is therefore vital for the industry. The third field is the adoption of application cases onto a microfluidic platform. In order to run in a miniaturised format, existing protocols and assays have to be modified with respect to reagent composition, volumes, flow rates, timing and other parameters. We have therefore established an application lab with possibilities for processes like biomolecule deposition, reagent lyophilisation, cell culture or real-time PCR to name just a few. In our experience, a successful commercialization of a microfluidic system needs to address all the issues mentioned above in addition to a thorough business planning. It is nice to see that more and more microfluidics-enabled products are making it onto the market.
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Introducing Editoral Board member Helene Andersson Svahn

In the second in our Introducing series, we’re very pleased to introduce Editorial Board member Helene Andersson Svahn to readers of the blog!

海伦·安德森Svahn

海伦·安德森Svahnreceived her M. Sc. in Molecular Biotechnology fromUppsala University和她的博士在电气工程处Royal Institute of Technologyin 2001. In 2002-2005 Dr Andersson Svahn was Marketing Director atSilex Microsystems。2003年,她被选为成员“TR100:35岁以下的创新者谁去创造未来”在麻省理工学院在美国。在2005- 2008年,她在教授生物MEMS应用在MESA +研究所在荷兰。2006年,安德森教授在Svahn从授予享有盛誉的研究奖学金瑞典皇家科学院新利手机客户端。在2011- 2012年,她的总统Young Academy of Swedenand she is also a member of科学的瑞典皇家科学院新利手机客户端。Currently she is heading theNanobiotechnology divisionRoyal Institute of Technologyin Sweden and CEO of the startup companyPicovitro AB(兼职)。她的主要研究方向是生物技术和医疗应用的微纳米流体设备。

研究视野: “TheNanobiotechnology groupatThe Royal Institute of Technologywas initiated in 2005 and consists today of approximately 20 people with a wide variety of backgrounds such as electrical engineering, medicine, biotechnology, chemistry and physics creating a very dynamic and interdisciplinary environment. TheNanobiotechnology group的重点是跨学科的研究重点,以纳米技术和微流控与各种生物技术和医疗应用相结合。在2013年的研究小组搬到了Science for Life Laboratory,这是瑞典一个新的国家资源中心致力于高通量生物科学为重点的健康和环境。新利手机客户端其目的是,SciLifeLab将成为欧洲领先的技术驱动型国家生命科学中心。新利手机客户端通过移动进入SciLifeLab,我的研究小组will have closer contacts with biological expertise which in combination with our cutting edge nanotechnology tools can help to maximize the output of these tools. For the future I believe that it is critical for the microfluidics field to develop a common language and understanding with biologists to enable us to shoulder biologically complex and technically demanding challenges.”
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Introducing Editorial Board Member Yoon-Kyoung Cho

In the first of a short series of blog posts introducing the newest members of theLab on a Chip编委会,在这里我们非常高兴地欢迎尹卓KYOUNG:

尹卓KYOUNGreceived her B.S. and M.S. in Chemical Engineering fromPOSTECHin South Korea in 1992 and 1994, respectively. She continued her studies in the USA at the伊利诺伊大学在那里她获得了博士学位厄巴纳 - 香槟分校(UIUC)的监督下,在材料科学与工程新利手机客户端,1999年Prof. Steve Granick。继她在伊利诺伊大学的毕业作品,她回到韩国的故乡,加盟Samsung Advanced Institute of Technology(SAIT) as a senior research scientist. During her nine years at SAIT, she was involved in the research and development of a wide range of lab-on-a-chip technologies for biomedical applications, several of which have made it to the commercial marketplace.

In 2008, she returned to academia as an assistant professor in the school of Nano-Bioscience and Chemical Engineering at the蔚山国立科技新利手机客户端(UNIST), South Korea and was promoted to associate professor in 2010. Since 2009, she has been the chair of her department and the director of an ambitious and prestigious program, the World Class University (WCU) program, geared to perform international research with leading scientists atUNIST。她目前的研究兴趣include novel micro/nano fluidic devices for advanced diagnostics, environmental monitoring, and cell biology. She has had a prolific career in academia and industry, publishing more than 38 scientific papers and 107 registered patents to date.

下面,赵教授股价她的浏览量Lab on a Chip和研究领域,她在目前的工作:

研究视野:““芯片上的实验室”是一个新兴的研究领域where new discoveries and innovations are realized through multidisciplinary thinking and miniaturization to solve today’s most challenging problems in human health, energy and environment. Beyond the classic definition of a device that can integrates multiple laboratory functions on a small sized chip, Lab on a Chip has advanced the fundamental understanding of biological systems, broadened the basic knowledge on the molecular interactions in nano-scales, and translated into innovative designs and engineering of novel materials, devices and processes in order to provide paradigm-shifting solutions to the complex issues in chemistry, physics, biology and bioengineering. It is expected that there will be more and more examples of Lab on a Chip that go beyond chip-scale test devices and provide real impact in clinics and industry. My research group, under the title of “Integrated Nano-Biotechnology Lab”, in the school of Nano-Bioscience and Chemical Engineering at UNIST, is focused on the development of Lab on a Chip systems with fundamental understanding of bio-molecular interactions and fluidic behavior in micro/nano scales and its smart implementation by utilizing various engineering tools. Current research interests include novel micro/nano fluidic devices for advanced biomedical diagnostics, environmental monitoring and cell biology; e.g., fully integrated lab-on-a-disc for bioanalysis, biosensors using novel nano-materials, and cell chips for the investigation of cell to cell communication in cancer.”
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HOT文章:人类血清葡萄糖测定数字微流体

Hywel Morganand colleagues at Sharp Laboratories of Europe, the University of Southampton and Sharp Corporation, Japan, demonstrate a large areadigital microfluidic arrayin this HOT article.

Using a薄膜晶体管(TFT)阵列而不是通常在电润湿电介质(EWOD)设备中使用的传统图案化电极,所述团队开发电介质(AM-EWOD)器件的有源矩阵电润湿。The TFT array enables each of the many thousand electrodes to be individually addressable, and the array is ‘fully reconfigurable and can be programmed to support multiple simultaneous operations’.

Read how the device can be used for measuring glucose in human blood serum in the full article (it’s free to access for four weeks*!):

Programmable large area digital microfluidic array with integrated droplet sensing for bioassays
B. Hadwen,G.R。布罗德,D.莫尔甘蒂,A.雅各布C.布朗,J.R。赫,Y.久保田和H.摩根
DOI:10.1039 / C2LC40273D

*Following a simpleregistration.

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Introducing our new Associate Editor – Dr Jianhua Qin

We atLab on a Chipare very pleased to announce our newest Associate Editor –秦建华博士。秦医生是在一个教授Dalian Institute of Chemical Physics(DICP),中国的院院士科学新利手机客户端(CAS) and is the director of theMicrofluidics Research Center在大连化学物理研究所。她加入了团队Lab on a Chipin July.

秦建华博士从中国医科大学和她的博士在化学中科院接受了她的医学博士在医新利手机客户端学科学,分别。新利手机客户端她在多伦多大学的博士后研究员。秦博士的研究兴趣集中于微流体技术和纳米技术相结合,了解自然的和不正常的BIOMED-系统上,导致新的诊断方案和治疗策略的设计。秦博士是化学物理研究所大连(大连化学物理研究所),中国院士(CAS)的教授,是在大连化物所微流体研究中心主任。新利手机客户端

Below, Dr Qin shares her views on the growth of microfluidics in China:

Microfluidics has emerged as a distinct new field to greatly influence the multidisciplinary research involved in chemistry, engineering, biology, and physics, as well as medicine. During the last two decades, it has been advancing at a rapid pace, and has found a variety of innovative applications worldwide. In China, only in the past decade, an increased number of scientists from different areas have been getting into this active field, leading to the rapid growth of microfluidics (or lab-on-a-chip) in China. During this period, more than 1900 scientific papers have been published in the international journals indexed in Web of Science, where the term “microfluidic” is used as a searching key word. Since 2002, a series of national and international conferences regarding the topics of micro/nanofluidics (or lab-on-a-chip) have been successfully held in China. These research activities cover subject areas including micro-scale fluidic control/principles, microfabrication technologies/methods, chemical synthesis/analysis, and biological/medical systems et al. It is of note that efforts in recent years have moved from simple technological demonstrations to the exploration of practical applications.

在中国这一研究领域的迅速增殖状态的主要原因是专用于医疗微流控技术的不断再认识,以及中国政府和其他资源,包括中国在内的国家自然科学基金,科技部的大量资金支持新利手机客户端中国科新利手机客户端学技术大学,中国科学院和行业等。该输入,极大地促进了科研设施,活动的改善和相关学术研究人员在许多高校和科研院所的培养。当然,在基础研究的快速发展和在中国的微流控芯片技术的发展,更多的挑战将面临并在不久的将来解决,如有效的战略,现有的微流体/ LOC方法应用到现实的应用和实现商品化。

我们很高兴地欢迎秦医生到Lab on a ChipEditorial Board as Associate Editor and feel that her expertise will help us to further meet the needs of our authors and readers.

If your research falls under Dr Qin’s area of expertise, why not提交你的下一篇文章给她吗?

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Introducing our new Editorial Board member – Professor Aaron Wheeler

We atLab on a Chipare very pleased to announce our newest Editorial Board member –Professor Aaron Wheeler。惠勒教授的主任Wheeler Microfluidics Laboratory在多伦多大学。下面,他解释了他是如何进入微流体,该领域面临的挑战,以及为什么他想成为一个曲棍球迷...

1.请告诉我们一个关于你的研究背景不大。

我做了我的博士在化学新利手机客户端与斯坦福大学的理查德“迪克”扎尔工作。我计划工作就与毛细管电泳的项目,但我开始后不久,迪克把我介绍给谁在微流体的“新”领域工作的博士后。几趟洁净室以后,我就迷上了,花了我的时间在斯坦福大学开发的微流体方法来分析单个单元格的内容。在完成博士学位后,我去工作的加州大学洛杉矶分校,在那里我学到了俗称为“数字微流体”或“电润湿的电介质(EWOD)”的技术与罗宾Garrell博士后。罗宾把我介绍给昌金“CJ”金乔噜了,我花了两年时间有一个爆炸的三个实验室之间来回跳跃,开发微流体和质谱之间的接口。(注意学生 - 做博士后这是你可以有一个科学家最有趣的。)然后我就开始了我的职业生涯是在多伦多大学的助理教授,现在我花了我的大部分时间躲在从我的同事们如此我可以用我对他们在实验室中具有乐趣的学生交谈。

2.第一次拿到你感兴趣的实验室在芯片技术作为一个研究领域是什么?

如mentioned previously, a postdoc in my Ph.D. lab, Keisuke Morishima (now a professor at Osaka University), introduced me to microfluidics. The rest, as they say, is history.

3. What do you think the most significant advance in LOC technology has been in the last 5 years?

It is difficult to choose – there have been so many exciting advances. One that sticks out is the方法由穆罕默德碳粉和他的同事为异构悬浮液中提取稀有细胞发育。当我与科学家在实验室上的单芯片社区外说话,这是最经常出现的话题。

4. What do you think is the biggest challenge facing lab on a chip researchers at the moment?

我们的现场继续与新的技术出来的“微流控专家”的实验室,并为最终用户手中的翻译奋斗。

5.你会给年轻的研究人员有什么建议刚刚开始自己​​的职业生涯?

投机取巧!学术科学家们需要写未来(即赠款)的非常详细的预测。良好的基金申请当然是一个重要的技巧,但我鼓励年轻的研究人员不被愚弄,以为科学会按照剧本!新利手机客户端最初的假设往往是错误(或实验探索它们变成是枯燥),但很有意思的现象比比皆是。睁大你的眼睛,并准备开拓新的和意外的意见。

6.如果你不是一个科学家,你会怎么做?

Hmm. I think I would try to be a part of the US National Public Radio show,RadioLab。If you are not a listener, check it out. I am a huge fan.

7. If you could meet anyone from history, who would it be and why?

Difficult question. I think I will go with Charles Darwin. (True story: I once was thrown out of Westminster Abbey by a large priest with a deep, booming voice for trying to make a charcoal rubbing of Darwin’s gravestone.) Darwin was obviously a source of important, transformative ideas, but he was interested in problems big and small. Apparently, he had a great passion for earthworms (!), going as far as to evaluate their behaviour over several decades by sprinkling markers on the ground to measure worm-driven soil turnover rates. I imagine that with some coaxing, a conversation with Mr. Darwin would cover almost any topic under the sun (or under the soil, as the case may be).

8.什么是你最喜欢的球队?

我在北卡罗莱纳州,在那里大学篮球几乎是一个宗教的国家长大。(真实的故事:有一天上六年级,媒体推车电视机被轧成所有的教室,我们花了一整天看NCAA大学篮球联赛,而不是学习什么,我们都应该做的分数或)所以,我(和我)北卡罗莱纳州(UNC)大学的粉丝 - 在我的成长期,那支球队特色的迈克尔·乔丹。(也许你已经听说过他吗?)自从来到加拿大,我试图成为一个曲棍球风扇。我想是多伦多枫叶队的球迷......但它是非常容易成为一个风扇,如果你的团队实际上赢得一些比赛。

We welcome Professor Wheeler’s expertise to the Board, and look forward to working with him over the coming months.

惠勒教授最近Lab on a Chippapers include:

数字微流体点胶试剂和细胞培养虚拟微孔
欧文A. Eydelnant,Uvaraj Uddayasankar,冰峪“贝蒂”李,孟闻辽,亚伦惠勒R.
Lab Chip, 2012,12, 750-757
DOI:10.1039 / C2LC21004E

对于复用的基于细胞的凋亡试验,一种数字微流体方法
Dario Bogojevic, M. Dean Chamberlain, Irena Barbulovic-Nad and Aaron R. Wheeler
Lab Chip, 2012,12, 627-634
DOI:10.1039 / C2LC20893H

A digital microfluidic method for dried blood spot analysis
Mais J. Jebrail, Hao Yang, Jared M. Mudrik, Nelson M. Lafrenière, Christine McRoberts, Osama Y. Al-Dirbashi, Lawrence Fisher, Pranesh Chakraborty and Aaron R. Wheeler
Lab Chip, 2011,11, 3218-3224
DOI: 10.1039 / C1LC20524B

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芯片上的实验室蟒蛇rd member and Wyss Institute Founding Director Donald Ingber receives 2011 Holst Medal

上周Wyss Institute for Biologically Inspired Engineeringat Harvard University awarded its Founding Director andLab on a Chip编委会成员,Donald Ingber, M.D., Ph.D., the2011 Holst Medalin recognition of his pioneering work exploring the cellular mechanisms that contribute to mechanical control of tissue and organ development, and his groundbreaking development of bioinspired technologies, ranging from organ-on-chip replacements for animal studies, to new engineering approaches for whole organ engineering.

The award was presented on December 16th at the High Tech Campus Eindhoven in the Netherlands during a ceremony at the close of the 2011 Holst Symposium, which focused on integrated heart repair. As the medal winner, Ingber also presented the 2011 Holst Memorial Lecture entitled “From Cellular Mechanotransduction to Organ Engineering.” Starting with an exploration of the role that cell structure and mechanics play in controlling tissue and organ development, Ingber’s lecture extended to provide a more comprehensive overview of his most recent innovations, including development of organ-on-chip microsystems technologies that recapitulate human organ functions, bioinspired materials that promote whole tooth organ formation, and injectable programmable nanotherapeutics that restore blood flow to occluded blood vessels.

“唐纳德Ingber取得了突破性到的细胞行为的力学生物学的理解贡献”的Joep Huiskamp,霍尔斯特纪念讲演奖委员会2011年秘书说,代表它。“Ingber最近一个呼吸的肺上的单芯片概念的发展是融合技术的杰出典范。”

This year’s Holst events were dedicated to the global health issue of heart disease, in recognition of its enormous emotional, medical, economical, and societal implications. The symposium brought together a few select leading international experts, including Wyss Institute core faculty member凯文·帕克套件博士,讨论心脏疾病,再生和修复的主要方面。帕克对工程心脏组织工作日前特色在Issue 24cover ofLab on a Chip(看到Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip).

唐纳德·Ingber,连同Lab on a ChipChair George Whitesides, will be guest editor of our final10th Anniversary issuefocusing on the USA which has the theme of translating research from the lab to the clinic, to be published next year.

从威斯研究所改编press release

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Free Lab on a Chip articles in Nature technology feature

发表在芯片实验室工作巨资拥有自然的最新特殊技术特点“Tissue models: A living system on a chip“。

文章,总结了当前国家的最先进的芯片上创建活组织模型,参考来自LOC编委工作Donald Ingber(Harvard Medical School) and LOC publications fromMichael Shuler(康奈尔),约翰·月(康奈尔),琳达·格里菲斯(MIT)和Axel Günther(University of Toronto).

我们已经取得了这些伟大的文章释放到2周的访问- 为什么不来看看!

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip
郑大世圆唱,Carrie Kam and Michael L. Shuler
Lab Chip,2010年,10,446-455

Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model
钟焕宋,郁佳杰,珞丹,迈克尔L.舒勒和John C.三月
Lab Chip,2010年,11,389-392

Perfused multiwell plate for 3D liver tissue engineering
Karel Domansky, Walker Inman, James Serdy, Ajit Dash, Matthew H. M. Lim and Linda G. Griffith
Lab Chip,2010年,10,51-58

A microfluidic platform for probing small artery structure and function

阿克塞尔半滑舌鳎,Sanjesh Yasotharan,安德烈Vagaon,康拉德Lochovsky,萨沙·平托,何经理杨,刘卡尔文,朱莉娅福伦达-Bolz和斯特芬 - 塞巴斯蒂安Bolz
Lab Chip,2010年,10, 2341-2349
From our2010新兴主题的调查问题

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