Toxicology Research blog

Aminolevulinate dehydratase (δ-ALA-D) is a metalloenzyme that has 3 vicinal thiol/thiolate groups that coordinate with Zn(II) and has been considered a reliable and sensitive marker of Pb(II) exposure.

However,in view of the presence of these vicinal thiol groups in its active centre,δ-ALA-D can also be very sensitive towards being oxidized by different soft electrophiles and by metals that compete with Zn(II) at its active centre.

In this reviewJoao B.T.Rocha,Cristina W.Nogueiraand colleagues from Universidade Federal de Santa Maria,discuss thein vitroandin vivoinhibition of δ-ALA-D by soft electrophiles,such as Hg(II),Cd(II),Sn(II),As(III),Bi(III),In(III),Tl(III),Se(IV) and Te(IV) as well as how δ-ALA-D can be a marker of oxidative stress in human pathologies,such as diabetes and hyperglycemia.

Find out moreabout how δ-ALA-D is more than a biomarker of Pb(II) but rather a universal marker of oxidative stress by reading the review today… it is free to access after all!

Aminolevulinate dehydratase (δ-ALA-D) as marker protein of intoxication with metals and other pro-oxidant situations
Joao B.T.Rocha,Rogerio A.Saraiva,Solange C.Garcia,Fernanda S.Gravina and Cristina W.Nogueira

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