When thinking about movement of the human body it is often thought about it in terms of muscles contracting and relaxing,joints bending and straightening,but I don't think I have ever thought about movement on a cellular level.
在运动过程中,我们体内的细胞受到机械力的作用,因此它们被拉伸,剪切和压缩。Many cells passively experience this force and some have even evolved to be particularly sensitive to it and act as sensors – such as the tiny hairs present inside the human ear.
然而,有些细胞更活跃,实际上可以对周围的环境施加自己的机械力。This interaction is used to achieve various physiological functions like the healing of tissue,对抗感染、细胞生长和分化。为了实现这些功能,细胞必须能够感知和理解周围世界的机械环境。
This review summarises the evolution of the area of 新利手机客户端science focused on understanding the mechanobiology of cells and tissues and how different properties of their surrounding environment can be analysed both scientifically and by the cell itself.It also goes further to discuss of different material properties effect the mechanosensing of cells. Whilst this is still a developing field this review gives a good overview of where our present understanding is at and what limitations there are to overcome in the future.
材料结构和力学性能在细胞-基质相互作用中的作用
Nicholas D.埃文斯和艾琳先生
JMater.化学。乙,2014,2,2345-2356.C3TB21604G
H.L.帕克是《材料化学杂志》博客的客座撰稿人。新利手机客户端她目前在绿色化学卓越中心工作,新利手机客户端约克大学。